منابع مشابه
Individualized medicine 2010
Molecular and cell biology have revolutionized not only diagnosis, therapy and prevention of human diseases but also greatly contributed to the understanding of their pathogenesis. Based on modern molecular and biochemical methods it is possible to identify on the one hand point mutations and single nucleotide polymorphisms. On the other hand, using high throughput array technologies, it is pos...
متن کاملGenetic variation and individualized medicine.
Mansell is with the Health, Physical Education, and Recreation Dept, Lincoln University, Lincoln University, PA. Tierney is with the Dept of Kinesiology, and Krynetskiy and Mishra, the School of Pharmacy, Temple University, Philadelphia, PA. Driban is with the Division of Rheumatology, Tufts Medical Center, Boston, MA. Clegg is with the Dept of Athletics, George Washington University, Washingto...
متن کاملPharmacogenetics, pharmacogenomics, and individualized medicine.
Individual variability in drug efficacy and drug safety is a major challenge in current clinical practice, drug development, and drug regulation. For more than 5 decades, studies of pharmacogenetics have provided ample examples of causal relations between genotypes and drug response to account for phenotypic variations of clinical importance in drug therapy. The convergence of pharmacogenetics ...
متن کاملIndividualized Medicine from Prewomb to Tomb
That each of us is truly biologically unique, extending to even monozygotic, "identical" twins, is not fully appreciated. Now that it is possible to perform a comprehensive "omic" assessment of an individual, including one's DNA and RNA sequence and at least some characterization of one's proteome, metabolome, microbiome, autoantibodies, and epigenome, it has become abundantly clear that each o...
متن کاملAdvances in Precision Medicine: Tailoring Individualized Therapies
The traditional bench-to-bedside pipeline involves using model systems and patient samples to provide insights into pathways deregulated in cancer. This discovery reveals new biomarkers and therapeutic targets, ultimately stratifying patients and informing cohort-based treatment options. Precision medicine (molecular profiling of individual tumors combined with established clinical-pathological...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2010
ISSN: 1582-1838
DOI: 10.1111/j.1582-4934.2010.01155.x